Sepsis and Urinary Tract Infections

Urinary tract infections, or UTIs, are common infections. They more frequently affect people with short urethras, including cisgender women, transgender women who have had vaginoplasty (surgery to create a vagina), and transgender men who have not had phalloplasty (surgery to create a penis). Most often, a UTI is treated quickly and effectively with antibiotics. Unfortunately, not all UTIs are treated quickly and some aren’t even identified, particularly among people who have limited or no sensation below the waist or who are unable to speak for themselves.

Untreated urinary tract infections may spread to the kidney, causing more pain and illness. It can also cause sepsis. The term urosepsis describes sepsis caused by a UTI.

Sepsis, which was often called blood poisoning, is the body’s life-threatening response to infection. Like strokes or heart attacks, sepsis is a medical emergency that requires rapid diagnosis and treatment.

Suggested Citation:
Sepsis Alliance. Sepsis and Urinary Tract Infections. 2023. https://www.sepsis.org/sepsisand/urinary-tract-infections/

Updated November 8, 2023.

 

More About UTIs

Definition

A UTI is an infection in the urinary tract, which runs from your kidneys, through the ureters, the urinary bladder and out through the urethra. The infections are very common and, in general, easy to treat.

A lower UTI, the more common type, affects the lower part of the urinary tract, the urethra and urinary bladder. Infection of the urethra is called urethritis and of the bladder is called cystitis. If the kidney is infected, called pyelonephritis, this is an upper UTI, as the kidney is the highest part of the urinary tract.

A UTI can be caused by bacteria (the most common type of infection) or a fungus.

Causes

The design of the human body makes it so it isn’t hard to get a bacterial UTI, because the infection comes from outside, through the urethra. Bacteria in the genital area can enter the urethra and the urinary tract, either through wiping after going to the bathroom, sexual activity, or unsanitary conditions. Once the bacteria have entered the urethra, the body tries to fight them off, but sometimes the bacteria multiply and cause an infection.

In the case of a fungal infection, usually the fungus gets to the urinary tract through the blood stream. Those who develop this type of infection are usually ill with a disease that has compromised their immune system, such as AIDS.

In general, people with shorter urethras get more UTIs than do cisgender men and transgender men who have had a phalloplasty, surgery to create a penis and lengthen the urethra. This increases with age. Statistics show that those with shorter urethras often get more than one over their life time. Almost 20% who have had one UTI will go on to have a second.

Symptoms

In the early stages of a lower UTI, you may feel:

  • Sudden and extreme urges to void (pass urine)
  • Frequent urges to void
  • Burning, irritation or pain as you void
  • A feeling of not emptying your bladder completely
  • A feeling of pressure in your abdomen or lower back
  • Thick or cloudy urine – it may contain blood

As the infection progresses, you may experience:

  • Fever
  • Pain in the lower flank, part of the back where your kidneys are located
  • Nausea and vomiting
  • Fatigue

Seniors may not show any of these signs or they may be too subtle for someone else to notice. An added symptom among this age group is confusion. Often, if a senior’s behavior changes suddenly, they may have an undiagnosed UTI.

Diagnosis

Most UTIs can be identified by symptoms and confirmed through a urine test.

If your doctor suspects that the infection has spread, you may need additional tests. These could include blood tests, scans of your kidneys, or a pelvic ultrasound.

Treatment

When caught early, it is usually easy to treat a bacterial UTI effectively. After confirming that you do have an infection, you will likely get antibiotics to fight the particular bacteria causing the infection. You also should drink a lot of water, to help flush out the infection.

It is essential that you complete your full prescription, taking all the antibiotics you receive, even if you feel 100% again. Even with the symptoms gone, the bacteria will still be present for a while and you need those antibiotics to finish getting rid of them. If you do not finish your prescription, there is a very good chance that the bacteria left behind will grow again, causing another infection. And, they may become resistant to the antibiotics that you originally used.

To treat a fungal UTI, your doctor would prescribe anti-fungal medications.

Prevention

In many cases, we can prevent urinary tract infections.

  • When cisgender women and transgender women wipe themselves after having a bowel movement, they should wipe from front to back, reducing the chances of stool touching the entrance of the urethra. Caregivers must do the same thing when providing intimate care.
  • After having sex, clean your genital area as the act of sex could push bacteria into the urethra.
  • If someone has a catheter, a tube that drains urine from the bladder, inserting the catheter must be in as sterile or clean an environment as is possible. As well, the urethral area must be kept clean, particularly of stool. Urinary catheters should not stay inserted for longer than necessary.

If you have frequent urinary tract infections, there are some steps you can take to try to reduce the number of infections you get. They include:

  • Drinking plenty of water every day, to help flush out your urinary tract.
  • Eat a healthy diet. Malnutrition, not consuming enough nutrients for your needs, can lower your body’s ability to fight infection.
  • Don’t hold your urine. Empty your bladder as frequently as is realistic and possible.
  • For cisgender women and transgender women, continue the wiping from front to back and cleaning well after sex.
  • Also some cisgender women find that diaphragms increase their number of UTIs, so if you are using a diaphragm, you may want to discuss an alternate method of birth control with your healthcare provider.

Related Resources

Information Guide

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Ruth Razey

November 30, 2020 I noticed chills and a very very slight feeling that I might have a UTI. (Sepsis and Urinary Tract Infections) I had just the week before had blood work done to get ready for a knee replacement that coming February. (I was 66 at the time) I was completely fine. December 1 I felt off and had more chills, thought for sure I had caught COVID so got tested. 3 days later results were negative but I was really not feeling well. I couldn’t bend my left knee. My family took me to an Urgent Care who ... Read Full Story

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Michelle H.

I learned a very valuable lesson that every woman should learn in the summer of 2022; NEVER DISMISS A UTI. I have had UTIs many times before. As usual, I texted my doctor and told her my symptoms and that I suspected it to be a UTI. She agreed and sent in a RX for antibiotics. That was Thursday. Saturday I’d been totally fine all day-until 6 pm. I crashed, crawled into bed for a “nap,” and didn’t get out of bed until Monday. I had little to nothing to eat or drink for 2 1/2 – 3 days. I ... Read Full Story

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Rosa M

On February 3rd my mother died from septic shock due to a long battle with a urinary infection that was not treated on time. (Sepsis and Septic Shock, Sepsis and Urinary Tract Infections) On October 2021 my mom had a urinary infection and her primary care did not give her antibiotics until one month after. This caused that her infection spread throughout her bloodstream and she started developing signs of sepsis such as trouble breathing, fatigue, extreme confusion, and extremely low blood pressure. She went on and off out of the hospital. By the time she was treated and she ... Read Full Story

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Natalie Zeleznikar

I was diagnosed with stage 1 breast cancer on my left side in 2015. (Sepsis and Cancer) I elected to have a double mastectomy as a friend had the same kind of cancer and chose a lumpectomy and three months later it went to other breast and she ended up with double mastectomy. I thought I was lucky to be stage 1, and really expected a six week recovery and didn’t worry. I was running an assisted living business as CEO and a few days before my scheduled return, friends came to see me. We had a glass of wine ... Read Full Story

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Julia Fraser

At the young age of 18, my life took a sudden and terrifying turn when I almost lost my life to sepsis. It all began with an untreated UTI, but the symptoms of a blood infection were not evident at first. Unaware of the severity, I went about my days until one morning, the situation escalated rapidly. (Sepsis and Urinary Tract Infection) In the earIy hours of June 19th, 2019 I was awakened suddenly, dazed, shaking and jolting uncontrollably, my skin was hot to the touch, but I had never felt more cold in my life. Little did I know ... Read Full Story

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Other Topics

Urinary Tract Infections (UTI)