Sepsis and Cellulitis

Cellulitis is a type of infection that affects the skin and the tissue underneath. The bacteria, most commonly group A streptococcal bacteria, enter the skin through an opening, such as cut, scrape, burn, or surgical incision, or even a bug bite or sting. Cellulitis can cause sepsis in some people.

Sepsis, which was often called blood poisoning, is the body’s life-threatening response to infection. Like strokes or heart attacks, sepsis is a medical emergency that requires rapid diagnosis and treatment.

Suggested Citation:
Sepsis Alliance. Sepsis and Cellulitis. 2026 https://www.sepsis.org/sepsisand/cellulitis/

Updated July 8, 2026.

 

More About Cellulitis

Symptoms

The infection is most common on the lower legs, but it can happen anywhere on the body. The symptoms of cellulitis include:

  • Redness around the area where the bacteria entered the skin
  • Tenderness, soreness of the affected area
  • Swelling
  • Blisters
  • Fever
  • “Dimpling” of the skin
Risk Factors

Anyone can develop cellulitis, but some people have a higher risk than others. If you fall into one of the higher risk categories, you should watch any injuries to the skin carefully.

  • Impaired immune system: People who have an impaired immune system are more vulnerable to contracting infections. These include people who are undergoing chemotherapy or who take corticosteroids. Visit Sepsis and Impaired Immune System to learn more.
  • Chronic illnesses: Illnesses like diabetes can increase your risk of developing infections. People with diabetes are particularly susceptible to getting sores on their feet and lower legs, which can become infected. You can learn more at Sepsis and Diabetes.
  • Skin conditions or disorders: Skin conditions and disorders can cause breaks in the skin. These include eczema, shingles, even so-called childhood illnesses like chickenpox.
  • Lymphedema: Lymphedema is a swelling of an arm or leg, most commonly caused by the removal of or damage to the lymph nodes as a part of cancer treatment. The swollen and stretched skin can crack.
  • Obesity: People who are obese have a higher risk of having cellulitis and of getting it again.
  • History of cellulitis: If you’ve had cellulitis before, you have a higher risk of getting it again.

People who are malnourished are also at higher risk of contracting infections.

Treatment

If you suspect you have cellulitis, see your doctor or nurse practitioner as soon as possible. If you need antibiotics, it is vital that you take them as prescribed, right to the end of the prescription, even if it appears the infection has gone away before the prescription bottle is empty. Ask your doctor or nurse practitioner when you should start seeing improvement. If you feel that the infection is worsening or there is no improvement despite treatment, you should have the infection checked again.

Celebrities

Learn about more celebrities who had sepsis from cellulitis and other causes here.

Related Resources

Information Guide

Cellulitis

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Allison B.

Ten months ago on a Tuesday, I developed what I thought were cold symptoms – a sore throat, low grade fever (100) and a swollen lymph node in my neck. Overall I felt okay, it wasn’t anything too unusual. By Thursday, my lymph node was VERY swollen. I called my doctor’s office, and they gave me some suggestions over the phone to help my throat, etc. Later that night, my fever went up to 103. On Friday, one of the doctors finally agreed I should be seen. He tested me for Covid and flu, but not strep because my throat ... Read Full Story

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Ann-Marie Carlson

I was fine one day and then couldn’t get warm the next. It didn’t seem that the cellulitis was worse, but I started running a fever. (Sepsis and Cellulitis) I was surprised at the hospital because I couldn’t stand up. They had to get a piece of equipment to get me to stand. I was thinking this is so very bizarre. Urgent care sent me right to ER, and up to Critical Care. Read Full Story

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Stephanie Lambert

On July 14, 2024, I stepped on a cat’s foot or tail and it bit me. Little did I know that despite seeking medical care and receiving my first antibiotic doses within 36 hours of the bite, that I would end up admitted to the hospital with secondary cellulitis and sepsis by the fifth day following the bite. (Sepsis and Animal Bites, Sepsis and Cellulitis) I was very fortunate that I made it to the hospital before I reached the point of having septic shock. Because the specific bacteria (Strep type A) was not identified until the third day of ... Read Full Story

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Jessica Quintana

February 2024 led to the scariest few months of my life. My eyes and skin turned yellow with jaundice and scans at the ER determined I needed a stent for a blocked bile duct tract. I’d been having horrible back pains since July 2023 and going to PT. These came and went but never tied them to health issues. Scans also showed I had gallstones. What was supposed to be a simple procedure turned out not to be. (Sepsis and Gallstones) I waited overnight for the surgeon. He placed a stent to open the tract. Cancer and autoimmune disease were ... Read Full Story

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Mary Rutherford

Mary B. Rutherford was my mom. In February of 2009, she suddenly developed symptoms that led to a diagnosis of primary brain cancer. That diagnosis was found after a whirlwind of doctor visits, tests, biopsies, and decisions. It was a fast-paced, emotional rollercoaster not only for Mom, but for me and my sister as well. Then we were blindsided. Once we received her cancer diagnosis, she was released from the hospital to a long-term healthcare rehabilitation center near where I worked. After spending a few days helping her adjust to her new routine, I returned to work. I was running ... Read Full Story

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Other Topics

Cellulitis

Cellulitis is a type of infection that affects the skin and the tissue underneath. The bacteria, most commonly group A streptococcal bacteria, enter the skin through an opening, such as cut, scrape, burn, or surgical incision, or even a bug bite or sting.