Sepsis and Respiratory Infections

A respiratory infection is any infection that affects your respiratory tract. It can be a common infection, like a cold, respiratory syncytial virus (RSV)  or viral pneumonia, or a rarer respiratory infection, like bacterial nontuberculous mycobacteria (NTM) or fungal histoplasmosis.

The infections are divided into whether they affect the upper respiratory tract and lower respiratory tract.  The upper respiratory tract includes the:

  • Nose
  • Mouth
  • Sinuses
  • Pharynx (upper section of the throat)
  • Larynx (voice box)

 

The lower respiratory tract includes the:

  • Trachea (windpipe)
  • Bronchial tubes
  • Lungs

As with any infection, respiratory infections can cause sepsis. Sepsis, which was often called blood poisoning, is the body’s life-threatening response to infection. Like strokes or heart attacks, sepsis is a medical emergency that requires rapid diagnosis and treatment.

Suggested Citation:
Sepsis Alliance. Sepsis and Respiratory Infections. 2026. https://www.sepsis.org/sepsisand/respiratory-infections/ 

Updated July 17, 2026.

More About Respiratory Infections

Symptoms

Symptoms of a respiratory infection depend on where in the respiratory tract the infection is. For example, if you have a sinus infection, you may have some of these:

  • Bad breath
  • Cough
  • Fever
  • Headache
  • Pain and pressure in the sinuses, behind your eyes, or even a toothache
  • Stuffy nose
  • Post-nasal drip

But if you have pneumonia, you could experience:

  • Cough
  • Fever
  • Shortness of breath
  • Sharp or stabbing chest pain when you take a deep breath
  • Rapid, shallow breathing

 

 

Treatment

Treatment of respiratory infections depends on the cause. Bacterial and fungal infections may be treated with appropriate antibiotics and antifungals. Only a few viral infections have an effective antiviral treatment. Usually, treatment for viruses focuses on the symptoms, trying to make you feel more comfortable as your body fights the infection.

Celebrities

Actor Robbie Coltrane died from sepsis that developed when he had an upper respiratory infection. Learn about more celebrities who had sepsis here.

Related Conditions

Andrew O.

Thought I had the flu (early Jan. in MN) had a tele health appointment and was diagnosed with flu. Two days later, no improvement. ER visit, told it was the flu, went home. Two days after this, ER again did blood tests, told my wife that I would have died within 48 hours. (Sepsis and Influenza) Five days in ICU, 12 days total in hospital. Mid foot amputation, right foot. It’s early July now and I am suffering from some severe mental health issues and always tired but can’t sleep. Thankful that my wife and kids haven’t left me. Read Full Story

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Dottie Badottie Ortega

I am a 37 yr. old mom of 2, I work part-time, homeschool my youngest, help run a weekly co-op, teach Sunday school classes and help chaperone youth group events, and sometimes I help my husband coach baseball. I have always been healthy and never took colds or other illnesses too seriously. I got sick Feb. 15, 2025. I was diagnosed with the flu on Feb. 18th, I had a high fever and a horrible cough and chills. I didn’t think much of it. I had heard the flu was really bad this year and I figured I had a ... Read Full Story

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Zach M.

January 14, 2019, I was getting a standard PICC Line procedure. This was to treat a chronic Lyme infection from years past. I felt fine before and afterwards. Whilst watching TV the next day, it felt as if I was having a heart attack out of thin air. Heart rate > 160, temperature > 106°. I couldn’t breathe, was uncontrollably vomiting, overheating, losing consciousness, chest pain, and more. I was quickly transported back to the hospital in an ambulance, where they would find I had both sepsis with acute organ dysfunction and influenza A. (Sepsis and Influenza) I would spend ... Read Full Story

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Georgia Matlack

In 2016, what began as a case of the flu and strep throat quickly turned life-threatening when the strep bacteria entered my bloodstream, triggering sepsis. I went into septic shock, and my organs began to fail. I spent a week in the hospital fighting for my life — a battle I’m incredibly grateful to have won. (Sepsis and Influenza, Sepsis and Strep Throat) Today, I’m fortunate to stand here as a healthy young woman, but my experience with sepsis has left a lasting impact. It has not only marked my past but also shaped my future. As Miss Route 66, ... Read Full Story

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Rebecca Ruano

I’ve been reading everyone’s stories about sepsis, and I have to say—after reading so many of them, I realize how much worse it could have been. In January of this year, my 7-year-old daughter caught the flu—influenza A. I picked her up from school, and she had a high fever. Of course, I kept a close eye on her the entire time. I even let her sleep in my bed because I was concerned. After three days of taking care of her, she bounced back completely and was fine. I crossed my fingers that her twin brother wouldn’t catch it—and ... Read Full Story

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Respiratory Infections