Some people who have sepsis end up having to get amputations but sometimes, people who have an amputation develop sepsis. A common cause is they get a pressure injury or pressure sore from their prosthetic or assistive device and this sore becomes infected.
For people who have sepsis, blood clots are a frequent cause of amputations. Your blood has many roles, one of which is to carry oxygen and nutrients to the organs and tissues throughout your body, from your brain to your smallest toe. After it provides the nutrients, the blood then collects the waste products and flows back to the heart and lungs for refreshing.
Usually, blood moves through your blood vessels (arteries, veins, capillaries) in a very fluid form. As your heart pumps, it drives the blood through the arteries. The blood clots only when your body senses it’s necessary. Once in a while though, the system causes problems. Clots might develop somewhere in the body where there shouldn’t be one. When a clot forms in a blood vessel, it can block the vessel completely, causing blood to back up, or the clot might only partially block the vessel, slowing down the blood flow but allowing some blood to pass through. Common examples of health problems caused by blood clots are deep vein thrombosis (DVT) and some types of strokes.
When someone has sepsis, the clotting mechanism works overtime. As nutrients can’t get to your fingers, hands, arms, toes, feet, and legs, the tissues begin to die and can develop gangrene. At first, your skin may look mottled, bluish purple, and then black. This dead tissue must be removed because it can cause infection to spread. If the gangrenous area is small enough, a surgeon may be able to remove just enough to stop the spread. However, if the damage is extensive, an amputation might be needed.
Sepsis, which was often called blood poisoning, is the body’s life-threatening response to infection. Like strokes or heart attacks, sepsis is a medical emergency that requires rapid diagnosis and treatment.
Suggested Citation:
Sepsis Alliance. Sepsis and Amputations. 2025. https://www.sepsis.org/sepsisand/amputations/
Updated May 8, 2025.