Sepsis and Kidney Stones

People who have had kidney stones say there is nothing more painful. Kidney stones can develop in one or both kidneys. Some people get one kidney stone in their lifetime; others can get them more often.

Urine has no solids, but there are times when the crystals in urine join together to form a stone. Although several substances can form stones, the four most common are made of:

  • Calcium – common and can recur
  • Cystine – an amino acid
  • Struvite – develop as a result of urinary tract infections (UTIs)
  • Uric acid – a crystalline compound

Your kidneys are the beginning or top part of your urinary system. Urine is filtered in the kidneys and comes down through the ureters into your bladder, one from each kidney. The urine is held in the urinary bladder until it is emptied when the urine passes through the urethra and out the urethral opening.

A risk with kidney stones is a kidney infection, which can lead to sepsis.

Sepsis is a life-threatening emergency that happens when your body’s response to an infection damages vital organs and, often, causes death. Like strokes or heart attacks, sepsis is a medical emergency that requires rapid diagnosis and treatment.

Suggested Citation:
Sepsis Alliance. Sepsis and Kidney Stones. 2024. https://www.sepsis.org/sepsisand/kidney-stones/

Updated February 16, 2024.

 

More About Kidney Stones

Causes

While we don’t know what causes stones to form, we do know that some stones form more easily than others. Dehydration and not consuming enough fluids can contribute to stone formation, as there may not be enough urine to wash out microscopic crystals.

Calcium stones, the most common kidney stones, seem to affect more men than women, and they are most often in the twenties when it happens.

Risks include:

  • Too much calcium in the urine caused by diseases, such as hyperparathyroidism
  • Having too much sodium, usually taken in through salt

Although food doesn’t cause stone formation, some people may be told to avoid high calcium foods if they are prone to developing stones.

Cystine stones are caused by a disorder that runs in families.

Struvite stones are virtually always caused by a urinary tract infection (UTI) due to an enzyme secreted by certain types of bacteria. Because people with shorter urethras have more UTIs, they also tend to develop more struvite stones. These stones can grow very large and block the kidney, ureter, or bladder.

Uric acid stones affect more men than women, and they can also occur in people who already get calcium stones. People who have high uric acid levels may have or develop gout.

Symptoms

Some people don’t feel kidney stones until they move and try to exit the kidney. Some symptoms include:

  • Sharp, severe, cramping pain in the abdomen or side of the back
  • Pain can move to the groin or testicular area
  • Blood in the urine
  • Chills
  • Fever
  • Nausea
  • Vomiting
Treatment

Because of the intense pain often caused by kidney stones, many people need pain relief. Many describe it as the worst pain they’ve ever felt.

If you have a kidney stone, you will be encouraged to drink a lot of water if you don’t have a medical condition that limits the amount you may have. The extra fluid is to help wash the stone through your urinary system.

If the stone doesn’t pass within a reasonable amount of time, your doctor may recommend extracorporeal shock wave lithotripsy (ESWL).  Shock waves are sent through to the stone to break them down into smaller pieces that can be passed. Sometimes, surgery may be needed.

The stone should be removed because of the high risk of infection, which could – in turn – lead to sepsis.

Prevention

While not all kidney stones can be prevented, there are ways to lower your risk of developing one or developing another one. The first and foremost way would be to drink enough fluids to ensure your urinary system gets flushed out well.

Your doctor could recommend avoiding certain types of foods, but that is an individual call. For certain types of stones, sometimes medications are prescribed to help reduce the risk.

Related Resources

Information Guide

Kidney Stones

  • To submit this form you are required to enter your first name, last name, a valid email address and your role.

Jillian Uyehara

The week of April 22 started as an ordinary busy week for me.  I teach at a preschool during the week, and I am a volunteer first responder, so I had classes each night that week. On Tuesday, we had a stomach virus in my classroom at school, so on Wednesday when I felt nausea hit me at school and some lower left quadrant pain, I was sure the stomach virus had found me. I asked to go home, assuming I would be sick 24 hours and then could resume my work and rescue classes.   On Wednesday and Thursday, ... Read Full Story

Submit Your StoryView More Stories

Melissa L.

I went to three doctors in as many weeks before my trip to the emergency room in February 2025. Something was wrong, but no one could figure it out. My symptoms were occasional stomach aches/back pain, lethargy, lack of appetite—basically I felt “off,” like a low-grade flu. I was tested repeatedly for Covid, strep, flu and UTIs, and they were always negative. After a night of sweats, then violent chills, I asked my husband to take me to the hospital, assuming I’d finally get my flu confirmation, a bag of fluids and some meds then be on my way. It ... Read Full Story

Submit Your StoryView More Stories

MistyAnn McMillan

It wasn’t my intention to pray, but as I rocked back and forth on my knees with my elbows stretched up the side of my bed, that’s how it would have appeared, and that is exactly when I realized I was in trouble. I had been sick for a couple of days with nausea, and a general unwell feeling but this day was worse than ever. I was alone in my bedroom with my children in their rooms doing the things teenagers usually do when their parents aren’t hovering. I grabbed my notebook and started writing from my position on ... Read Full Story

Submit Your StoryView More Stories

Catherine Benton

Hi! My name is Cat. I’m a sepsis survivor. On January 9, 2025, there was a snowstorm headed towards Arkansas which I must admit, doesn’t happen often. The 3 weeks prior I had experienced urinating pain, fever, rapid breathing, and swelling. It didn’t matter what I did, it just got worse. I had no medical insurance at this time so I shrugged it off. I’m also a diabetic. So on that day while en route to finally see my doctor that my mother was going to pay for. I collapsed at his office. (Sepsis and Urinary Tract Infections, Sepsis and ... Read Full Story

Submit Your StoryView More Stories

Liz P.

Friday the 13th, yes, Friday the 13th! A beautiful autumn day in October 2023 was a routine day for my husband and myself, a retired, relatively healthy couple aged in our mid seventies. While preparing to retire, later in the evening than usual for us, and feeling the need to urinate, my attempt was unsuccessful. After several additional attempts, but without pain, I made a mental note to contact my physician in the morning, believing I might have a UTI. A decade earlier, I had, with great pain, passed a kidney stone without difficulty, but had experienced the same earlier ... Read Full Story

Submit Your StoryView More Stories

Other Topics

Kidney Stones